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in the Beijing Economic Development Area, a dozen acres of production plant, the area stood alone, a little three story house. First floor office area, second floor is the research and development areas and quality control room, three is the production workshop. Hundreds of square meters of production workshop, a hundred Thai students Teshin Biological Pharmaceutical Co., Ltd. (hereinafter referred to as a hundred Thai biological) production of unique products, annual output of not more than 7 kg, however, the output value to create more than 200 million yuan.
for the recent introduction of the \the biotechnology industry as one of the seven strategic emerging industries, but also hope the Government will implement the relevant policies as soon as possible. \Tektronix has successfully developed the world's first personal source of the monoclonal antibody drug (hereinafter referred to as monoclonal antibody drugs), has taken the first step in the industrialization of monoclonal antibody drugs. Up to now, monoclonal antibody drugs have been successfully applied in cancer therapy, treatment of autoimmune diseases, is the most important development of biological medicine one of the areas. However, high technical threshold, investment,louis vuitton shoes, making the world's drug companies have only a Genentech monoclonal antibody (Roche, a wholly owned buy later), Amgen, GlaxoSmithKline, which are not more than eight, while the percentage of biological Thailand be among them.
1998, the Genentech's success that when he was 50-year-old Bai Xianhong initiation of entrepreneurial ideas. After Baixian Hong spent two years to raise funds, found more than 50 banks and companies, but few people are willing to invest, almost no one thinks that over fifty people can succeed. Ultimately, Beijing Tai Cheung lean persuaded by his company, has invested hundreds of biological and Thailand, and Cuba's Molecular Immunology Center through the sale technology, biotechnology and Thailand accounted for 25% of a hundred shares.
2000, the financing is completed the formal establishment of bio-hundred Thai, Bai Xianhong also through partners to introduce the Cuban Center of Molecular Immunology in Cuba a number of single antibody drug technology. However,juicy couture handbags, in order to come up with a real product, the technology is still a hundred Thai biological step past the first hurdle to be. At that time, monoclonal antibody technology and process is mainly controlled by Genentech, Amgen and other companies hands, but the company kept strictly confidential.
antibody technology is the percentage of human biological facing Thailand a major technical difficulties. Bai Xianhong said that the difficulty of human technology is that it requires a lot of discipline integration is very complex. It needs to mouse cells with antibodies, similar to transformed into human cells. Involving computer simulation, molecular biology, biochemistry, computer science and other disciplines, any amino acid change will affect the protein structure, activity, requiring ongoing student representative.
until 2002, completed a hundred Thai pre-clinical biological research, students in the sample out of the Teshin this, began to enter the clinic. In 2005, a hundred Thai biological drugs in the Food and Drug Administration to get a certificate.
However,juicy couture tracksuits, the industry has become the face of hundreds of other Thai biological problem. Biological products and medicine, chemical medicine is different from the experiments in the laboratory to quantify the production is a very big leap forward in technology, how the process of the laboratory into a production line, how to plant planning, to which a particular laboratory conditions , would require very cautious, to explore their own.
In addition, the layout of the production line, traditional pharmaceutical companies can learn from peers, but the monoclonal antibody drugs is different, the device is not standard products, all customers need their own separate custom made. Can not find a hundred Thai biological counterparts in the domestic and foreign pharmaceutical giants are on the production line as the core technology and strictly confidential. Bai Xianhong recalled, \After a set of equipment to do their own Zhaomaohuahu planning, and then with the equipment suppliers after several months of coordination, the need to finalize what equipment, how the signal output, to determine the final production line program. A year later, production equipment was finally manufactured and shipped to a hundred Thai life. At this point, the company began production of active commissioning. Debugging time, engineers are 3-4 months after midnight to go home.
Baixian Hong sighed again, \Card finally successful listing, as the only a single antibody drugs.
new drug R & D \
According to Bai Xianhong introduced Teshin lifetime investment of time after about 10 years, before and after the funds invested 3 billion yuan, \p>
Baitai the early days of biotechnology, the team only a dozen people, the house was rented in the suburbs, a two-tier small duplex, and in order to complete the work, everyone had to wear many hats. Drug research and development director at the time application is part-time, the civil work on the new plant is the Fuzongjingli in Hongkong from now responsible for the clinical students were Taixin data collection, but also in Hongkong spent several months time, traveled all over the Fujian Guangdong, Guangxi and other provinces, a collection of a doctor from the clinic came up.
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2004 per year is the most difficult year of biological and Thailand, the product is applying for new drug certificate, however, whether the application is successful, the number who do not mind, but this time the company's financial were rattled. Bank loan, the bank saw financial condition, just no money proceeds, but nothing can be secured, of course, do not give loans. Looking for investors? Approval of new drugs has not come down, there is simply not discussed.
Baixian Hong've had some domestic well-known pharmaceutical companies, with others an introduction to the situation, people do not cold, not interested. Then finally on a good with a state-owned enterprises, and the results the day before the contract suddenly informed that, do not vote, and was feeling really can not hold out.
desperation, Bai Xianhong had to call around with friends to borrow money, borrow 20 million today, tomorrow, by 30 million, although by a lot of money, but for the company, still could not hold it a few day, Raining Cats and quickly took out.
Baixian Hong said,juicy couture outlet, \has a very strong. \flow, when sales of over billion, last year, nearly 200 million in sales.
Merck's Erbitux is currently the nearest hundred Thai biology, the most comparable products. Bai Xianhong said, compared with Erbitux,moncler, a hundred Thai products in some areas of biological data has been more than Erbitux.
single antibody drugs through four stages of development, namely, mouse monoclonal antibody, mouse - human chimeric antibody, humanized antibody, antibody-round. Erbitux is the number of embedded and antibodies, humanized only 70%; and Teshin students belong to the third generation of human antibody drugs, human source of more than 90%. Because of the high proportion of human,pandora bracelets, drug adverse reactions are relatively much smaller, much better security. Pharmaceutical and Biological Products in China after the identification, purity and activity Teshin students also are higher than Erbitux. Thailand's immediate goal is a hundred more than Merck's domestic sales, became the first place.
and multinational companies, but compared to the scale of a hundred are still far from biological Thailand. To Genentech, for example, its name has several single-antibody drugs, and monoclonal antibody as the general interest due, Group Secretary beads monoclonal antibody, bevacizumab monoclonal antibody drugs such as sales of more than a few billion dollars.