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... _2295,[link widoczny dla zalogowanych]
Department of Otolaryngology patients with malignant tumors of serum superoxide dismutase activity and lipid peroxidation? ...

In recent years, concern about the relationship, many cancer patients on serum superoxide dismutase (sOD) reported decreased activity. But the Department of Otolaryngology lipid peroxide in patients with malignant tumors (MDA) level of change reported rare. 1994 to 1996, we treated nasopharyngeal cancer, laryngeal cancer, and malignant tumors on award a total of 4O sinus inverted, is its level of serum SOD and MDA were detected and compared with the normal order of SOD, MDA and the the relationship of tumor incidence. Reported below. 1 Data and methods 1.1 Clinical Data 4O patients,[link widoczny dla zalogowanych], male and 3O,[link widoczny dla zalogowanych], female aged 25 i 1O cases 65 years,[link widoczny dla zalogowanych], an average of 46 years. All confirmed by pathological examination. 3O cases where nasopharyngeal carcinoma (NPC group), and pathology of 28 cases of poorly differentiated squamous cell carcinoma, moderately differentiated squamous cell carcinoma 1 down, 1 case of undifferentiated carcinoma; carcinoma in 5 cases (laryngeal carcinoma), and pathology in a high differentiated squamous cell carcinoma in 2 cases, 3 cases of poorly differentiated squamous cell carcinoma; maxillary sinus cancer 5 down (maxillary sinus cancer group), and pathology of malignant lymphoma in 3 cases, poorly differentiated squamous cell carcinoma 2 down. In both normal healthy people the same age as the control group of 47 down. 1.2 Detection Methods All patients before radiotherapy or surgery in the morning before 8 am asked fasting blood pumping, separation of serum, the same day into the determination of SOD and MDA. Also the same time the control group. SOD activity was measured by the level of xanthine oxidase tMDA determined by thiobarbituric method. Kit by Nanjing Jiancheng Bioengineering Institute. 2 Results Group 3 patients and control group in peripheral blood SOD and MDA in the First Affiliated Hospital of Kunming Medical College, Department of Otolaryngology shaking (Kunming .650031). First Affiliated Hospital of Kunming Medical College, Central Laboratory of the measured values in Table 1. Table 1 shows, NPC group,[link widoczny dla zalogowanych], laryngeal sinus tumor group and the group awarded the vitality of SOD was significantly lower than the control group. Decline of 13 tumor group, SOD and MDA levels compared with the control group (persons) compared with control group, P> 0.05, 'P <0.01 NPC group was significantly higher MDA content, but laryngeal group and maxillary sinus cancer, compared with the control group no significant difference. 3 Discussion Free radicals are unpaired outer orbital electron atoms or molecules of special status, is the body use oxygen superoxide generated in the process. Normal production of free radicals, and the elimination of the question, using the existence of dynamic balance. When smoking, alcoholism, HIV infection and ionizing radiation and other damage, leading to the generation of superoxide free radicals and the elimination of imbalance, the superoxide radical and hydrogen peroxide accumulation to a certain concentration, can be harmful free radicals within the cell chain start the reaction, damage to phospholipids, proteins, nucleic acids, etc., to induce loss of normal function and disease. SOD is to remove the body to free radicals into harmless water and oxygen an important enzyme. SOD activity changes reflect the ability of the body against free radical damage. We 3O cases of NPC, 1O down 5 down the maxillary sinus malignant laryngeal and serum SOD activity and MDA levels detected, 3 patients were significantly lower than the vitality of sOD the control group, the difference was statistically significant; NPC group and the content of lipid peroxides are significantly higher than that of organized cell damage in vivo in patients, and host defense ability to reduce oxygen free radicals, which may be related to the pathogenesis of NPC} but the other two types of cancer, MDA did not change the number of cases may be less relevant. (Received l998-07-23) (Editor weeks as new), The book systematically introduces the ears, nose, pharynx, larynx, trachea, esophagus and head and neck embryology, anatomy, physiology, basic knowledge of inspection methods, the Department of Otolaryngology focuses on the common disease etiology, pathology, I clinical manifestations, diagnosis and differential diagnosis, treatment, etc., reflect the latest progress at home and abroad. Book 220 million words, 1,500 pages, 2,000 illustrations, hardcover, You Goujia 169 yuan. Another element t Book buyers please remit to PO Box 292, Tianjin Star Lu Youju Tel O22-27230475.