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Patients with gastric cancer urokinase-type plasminogen activator and its receptor in the clinical significance of

Abstract Objective To study the gastric cancer patients urokinase-type plasminogen activator (u-PA) and its receptor (u-PAR) and its clinical significance. Methods 30 patients were determined by ELISA with gastric cancer and 30 cases of normal plasma u-PA and u-PAR content. Results Preoperative plasma u-PA and u-PAR content with the control group there was significant difference (P 0.05); has been transferred by u-PA and u-PAR was significantly higher than those without metastasis (P Key words gastric cancer u-PA u-PAR urokinase-type plasminogen activator (u-PA) and its receptor (u-PAR) is a recent fibrinolytic factors of particular concern to them in addition to fibrinolysis, but also involved in extracellular matrix degradation, cell repair and tissue remodeling process. Therefore these two factors and tumor biological behavior and prognosis of patients [1 ~ 3]. For cancer, RT-PCR,[link widoczny dla zalogowanych], many scholars studied in gastric cancer u-PA and u-PAR protein levels [4], while for small sample research. In this paper, 30 cases of gastric cancer patients with u-PA and u-PAR levels were tested to evaluate their clinical significance. 1 Materials and methods 1.1 General information on 30 cases of gastric cancer patients, 20 males and 10 females, aged 41 to 80 years, mean 57.3 years old, were diagnosed in our hospital of the patients. Normal control group of 30 patients, 18 males and 12 females, aged 28 to 65 years, mean 35.5 years old, were healthy hospital workers. 1.2 methods morning fasting venous blood, into the containing 0.109 mol / L sodium citrate solution anticoagulant reagent tube 9:1, 3000r/min, centrifugal 10min, the supernatant plasma Home -20 ℃ refrigerator, under test. Gastric cancer patients before surgery and 2 weeks after specimen collection. u-PA and u-PAR was detected by ELISA method kit for the US Assocition and Geneengineering company. 1.3 Statistical analysis of data expressed by x ± s, compared with paired t test. 2 results 2.1 gastric cancer patients before and after operation plasma u-PA and u-PAR levels of 30 cases of gastric cancer patients compared preoperative plasma u-PA and u-PAR were higher than those in control group, the difference was significant (P 0.05) (Table 1). Table 1 gastric cancer patients before and after operation plasma u-PA and u-PAR level was