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Differential proteomics in screening of tumor markers

Colleagues analyzed using SELDI-TOFMS technique in renal cancer cells and normal cells,[link widoczny dla zalogowanych], protein levels,[link widoczny dla zalogowanych], detected differences in the protein. Hlavaty and other use of this technique in patients with serum prostate-specific proteins identified,[link widoczny dla zalogowanych], molecular weight 50.8x103. As a prostate tumor marker protein. Recently. Petricoin and other U.S. technology with SELDI-TOFMS serum from ovarian cancer were screened five marker protein when further testing of clinical samples,[link widoczny dla zalogowanych], the sensitivity was 100%, specificity 95%, the positive rate was 94%. These instructions SELDI-TOFMS can effectively distinguish between tumor and normal tissue changes in protein composition. Tumor markers can be used as an effective screening tool. 6 Looking Differential proteomic research with new ideas and technologies continue to emerge. Will be separated and detected in low copy number and high molecular weight protein acidic and basic proteins. Will be to develop economical, fast and reliable means for protein identification. The emergence of new technologies can facilitate a comprehensive analysis of the researchers state of health and disease protein. Obtained from these technologies will make information astonishing leap in cancer research occurred. For cancer diagnosis and provide new therapeutic approaches.