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Dołączył: 29 Lip 2010
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 Wysłany: Nie 12:07, 03 Kwi 2011 Temat postu: Tremella polysaccharides in the treatment of hepat |
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Tremella polysaccharides in the treatment of hepatocellular carcinoma and its mechanism of experimental study
ceractivatedbyCTXandTremellaPolysacchariderespectivelyweredetected. Toexaminetumorweight, size, histologicalchangesandmorphologica1changesinmainviscera. ThecytotoxicityofCTLactivatedbyCTXorTPorCTXandTPtoP815. HACandB16wasdetectedbyT-scintillationcounterafter4hours. ResultsThenumbersoftotalTce11s. Tkillerce11andtheactivityofTNFinmicereceivedTPwerehigherthanthoseofthecontrolmice, especia11ythetota1numberofTcellandtheup-regulationofTNF. ThepercentagesoftumorgrowthinhibitiononHAC,[link widoczny dla zalogowanych], P815andB16were23.85% 20.81% and25.43% respectively, whichwerehigherthanth0seofthecontrolmiceandmicetreatedwithCTX (P <0.01). ToB16, thecytotoxicityofCTLwasthestl_0ngest. ToH22, thecytotoxicityofCTLwasstrongerandtoP815, thecytotoxicitywastheweakest · TheDrecedingtargetsofCTX + TPgroupwerelowerthanthoseofTPgroup, butsignificantlyhigherthanthoseofCTXgrouporcontrolgroup (P <0.05). Tumorweightandsizeintreatmentgroupwereobviouslyl0werthanthoseof ∞ ntrolgroup. However, necrosisoftumorwasmoreseriousandextensive-TherewereDrominentinfiltrationoflymphocytesandmonocytes. Thehyperplasiaoffibroustissuewasalsooutstanding-ThepresentationonCTXgroupwasmoresignificantthanthatinTPexperimentgroup-Exceptspleen, therewasnosignificantmorphologicalchangesonmainvisceralorgansinTPexperimentgroup. ConclusionTPmavbeananti-tumortraditionalmedicinewhichcanactivateandenhancethespecificandnon-specificcytotoxicityactivities, inhibitsthetumorgrowthandregulatestheimmunefunctionsofhost-Keywords: TremellaPolysaccharide; Transplantedhepatocarcinoma; Biotherapy 【 Editor : Chen Lihua 】
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