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Hepatitis G virus infection on chronic hepatitis B and pathology of

Chu Tang Jianguo Zhang brightness in the five-cylinder Ang Zhou Xiumei dust off t words hepatitis G virus; Hepatitis B; Pathology DOI R512.6 books and materials for the present observation of hepatitis G virus (HGV) infection on chronic hepatitis B (CH-B) influence on the CH-B treated in recent years, 121 patients with serum specimens were down HGV-RNA detection, wells will be one of consolidation and merger HGV infection has not conducted a comparative clinical and pathological study are reported to have been as follows. 1 Materials and methods argue down 1.1 object 121 patients positive for serum HGV-RNA infection were divided into two groups. Co-infection group of 20 down, down male and 15 female 5 down, the average age of 3I. 7-year-old, n do have history of blood transfusion or blood products of aluminum on the Xi group lO1 down}, in which 70 male and female 3l down, average 36.2 years old valve. Diagnosis of all those who were negligent in May 1995 according to the fifth shift = Beijing National Conference on Infectious and Parasitic Diseases revisions of viral hepatitis prevention and treatment programs. f ~ - / 2.6 o21.2 conventional method to detect alanine aminotransferase (ALT), total bilirubin (TBIL), albumin (ALB), globulin electrophoresis (a EP), prothrombin activity (PTA ) f yeast linked immunosorbent assay (ELISA) assay HB ~ Ag, anti-a HBs, HBeAg, anti-a HBe, anti-a HBc, anti-HBc-IgMf a polymerase chain reaction (PCR) detection of HBV-DNA; reverse polymerization polymerase chain reaction (RT-PCR) detection of HGV-RNA. Kit were biotechnology company Shanghai Branch of China and Beijing Medical University, Institute of Liver Diseases products. Menghini method of liver biopsy, HE stain, light microscopy, two patients experienced doctors reasons for the prevention and treatment programs in accordance with the common diagnosis. 1.3 persons indicated statistical data, t test with Yuan test. 2 Results 2.1 Comparison of the two groups were the main biochemical indicators (Table 1). Table l Comparison of biochemical indexes of the two groups were the main two groups Note t tP> 0.052.2 two groups of patients HBeA ~ g, HBV-DNA positive serum levels of infection compared well together HBeAg, HBV-DNA positive were 13 (13 / 20) back,[link widoczny dla zalogowanych], H (14/20) down; the control group were 72 (72/101) down, 74 (74/101) fell between the two groups did not differ significantly (P> O.05). 2.3 Comparison of two groups of liver pathological injury (Table 2,3). 2 bad liver inflammation activity in the two groups were compared Note the two groups, P> 0.05 Table 3 Comparison of two groups of patients with liver fibrosis compared injection of two maggots, P> 0.053 on the current number of studies have showed that, HGV and HBV has a similar route of exposure, it is clinically CH-B patients with HGV infection is common. The results of this study found that CH-B cut combined election HGV infection 16.53,[link widoczny dla zalogowanych], and further support the above conclusion. On the pathogenicity of HGV, a larger current debate, there are two views,[link widoczny dla zalogowanych], a view that the pathogenicity of HGV strong and can cause various types from light to heavy hepatitis, while another view was that no HGV To just flat wrong or weak pathogenicity. HGV infection in the same combined effect of CH-B, but also differences. The results show that for mergers and unincorporated groups CF1B HGV garlic dyed and other biochemical markers of liver function, serum HBeAg, HBV-DNA positive rate of liver lesions in inflammatory activity and fibrosis were not different between the degree of star significance (dead> 0.05). Thus indicating that the combined HGV infection does not increase the CH-B Well liver damage,[link widoczny dla zalogowanych], does not affect HBV replication,[link widoczny dla zalogowanych], while the pathogenicity of HGV may be prompted to weak. (1998-10-05 miserable return received Meng 1999-06-23) (car text editor Zhou Guotai) ① Long County Hospital of Shandong soup
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