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Chronic bronchitis, emphysema,[link widoczny dla zalogowanych], pulmonary heart disease in patients with plasma D-dimer and platelet aggregation and significance of the changes

COPD (emphysema), chronic pulmonary heart disease (Cor) fibrinolytic activity and platelet function and significance of the changes, some of our co-infection of chronic bronchitis, emphysema, pulmonary heart disease before and after in infection control in patients with plasma D-dimer and platelet aggregation (PAgT) measurement, compared with normal control subjects. Are as follows. 1 Data and methods 1.1 Clinical data of 16 patients with chronic bronchitis, 10 males and 6 females, mean age 62.02 ± 7.54 years; emphysema in 14 cases, 9 males and 5 females, average Age 63.51 5.26 Earth years; 21 patients with pulmonary heart disease, 13 males and 8 females, mean age 65.86 ± 6.42 years. The three groups were acute exacerbation of patients (in varying degrees of pulmonary infection). Examination control group of 20 healthy elderly patients, 13 males and 7 females,[link widoczny dla zalogowanych], mean age of 64.29-+ -5.73 years. 1.2 Methods After three groups of patients were admitted to hospital with antibiotics to control infection (not used drugs affect blood coagulation and fibrinolysis), infection control were drawn before and after the cubital vein (control group, a pumping elbow vein), sodium citrate anti- After centrifugation,[link widoczny dla zalogowanych], plasma coagulation,[link widoczny dla zalogowanych], latex agglutination test with D-dimer; the same method used turbidimetric method to measure blood PAgT. Data analysis by t test. 2 results of three groups of patients before and after treatment of plasma D-dimer and PAgT Change Annex. Can be seen from the table, the first three patients infected with the control of plasma D-dimer and PAgT were significantly higher than that, wait a minute branch,[link widoczny dla zalogowanych], emphysema, pulmonary heart disease in patients with plasma D-dimer and PAgT in turn the rise , the difference was significant. Infection control, the three groups of D-dimer levels were significantly decreased (but not emphysema, pulmonary heart disease is still higher than the control group), PAgT reduction in the level is not obvious. Schedule three groups of patients before and after infection control plasma D-dimer and PAgT changes (X ± s) Note: Compared with control group, P <O. 05, △ P <O. Ol; compared with before treatment, a P <O. 05; and a monthly group, P (O · 055 discussions cells, neutrophils, etc., to release a series of vasoactive plasma D-dimer is cross-linked fibrin degradation substances (such as prostaglandins and white ene, thromboxane, platelet formation with Y, a Y, the chain degradation of fibrin-specific activator, etc.), causing platelet adhesion, aggregation and increase material is fibrin degradation products in the smallest fragments can be strong, so may promote thrombosis of small pulmonary arteries, leading to secondary fibrinolysis in vivo, or reflect the hypercoagulable state. hyperfibrinolysis previous research table, plasma D-dimer levels increased. we have invented, in chronic bronchitis to emphysema disease process, the patient's blood is, chronic bronchitis, lung lung infection control in patients with pulmonary heart disease began to emerge after the D a prothrombotic state, there obstructive pulmonary emphysema dimer levels were significantly decreased, PAgT also decreased the level of trend arterial thrombosis rate as high as 2O ~ 50, with pulmonary potential, but still higher than before infection control, indicating that the infection on secondary fiber hypertension thrombosis is higher. This showed that chronic bronchitis, dissolved a greater impact, the reason bacterial infection may be patients with emphysema and pulmonary heart disease in acute plasma D-dimer of fibrinogen to speed up the conversion rate, or the fiber protein in patients infected with the content and DAg'I, were significantly higher in indicates that the white (original) increased due to degradation products. So that, for chronic bronchitis, classes exist in vivo in patients with hypercoagulability and fibrinolysis in hyperthyroidism. The reason for lung lung, pulmonary heart disease is the use of appropriate anticoagulant therapy may be feasible chronic bronchitis, emphysema and pulmonary heart disease patients with hypoxia, and it may delay the development of chronic bronchitis to pulmonary heart disease process. hypercapnia and high blood viscosity and other factors, in addition to lung infection Add 6-29 '1998 Received) can be induced swelling of vascular smooth muscle adjacent to the endothelial cells, macrophages 28 *