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Metallothionein expression in gastric cancer and its significance

Metal ions and some hormones related to induction of endogenous factors , but so far no specific MT inducer , inducer MT common cause many other side effects. MT synthesis mechanism in cancer cells is not clear. MT can be combined with various metal ions , heavy metal detoxification mechanisms in the human body , in which more research is the relationship between cadmium and MT ,[link widoczny dla zalogowanych], most of the body and the MT with cadmium , mainly in the liver and kidney. MT of the toxic dose of cadmium induced liver injury in rats [ cited , MT toxicological effects of cadmium with the application of transgenic animals deepening its research ,[link widoczny dla zalogowanych], the liver MT can be reduced cadmium excretion from the bile . It is reported that high levels of liver zinc and MT on the presence of zinc may be involved in protective effects on the liver MT [ . In addition , MT , and the relationship between colon cancer 10 * have been reported _6 ], in the neighboring normal tissue of colorectal cancer , MT expression were very high, with very little expression of p53 , MT expression may be the high occurrence of colorectal cancer An important sign of early . Current research focus on the MT is its resistance. Some [ 】 manned MT gene transfection of mouse C127 papillomavirus type cells ,[link widoczny dla zalogowanych], MT to 10 times the original content ,[link widoczny dla zalogowanych], such cells to carboplatin, chlorambucil, and other anti- L- phenylalanine 10-fold increase in potency . This study demonstrates that MT expression in gastric cancer was 54.55% , while the mucus adenocarcinoma in 28.57 % (2 / 7) ,[link widoczny dla zalogowanych], which the report _7JMT rarely in mucinous carcinoma of the expression of similar. Resistance of MT for further research , and should be extensively carried out the detection of drug resistance gene , especially for multi-drug resistance protein in the detection of cancer chemotherapy program development will be instructive .
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