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Gallbladder tissue expression of COX-2 and correlation of

29) was significantly higher than the expression of COX-2 negative cases (2O,[link widoczny dla zalogowanych], 2 / 10) (P <O.05). Rate of COX -2 expression with histological grade, tumor size , patient gender, age are nothing to do with patient prognosis. This indicates that COX -2 expression and biological behavior of malignant gallbladder was a significant positive correlation. Gallbladder cancer is highly malignant tumors , there is no effective control methods , only a very small number of patients after radical operation can survive more than 6 months . Study confirmed c0x -2 in colon cancer tissue was overexpressed COX -2 inhibitors long-term use and colon cancer incidence was significantly negatively correlated , can the relative risk of colon cancer decline 4O ~ 6Old], and the use of high selection Of COX -2 inhibitors can successfully control the occurrence and development of colon cancer l5]. Wu Gaosong other _6 study found , COX-2 selective inhibitor Celecoxib can be reduced gallbladder carcinoma GBC-SD cells, COX -2 protein expression , significantly inhibited the proliferation of GBC-SD and induction of apoptosis , and these effects were time and dose Dependent. The study also found , Celecoxib could significantly inhibit the release of gallbladder carcinoma GBC-SD cells PGE2, and Celecoxib inhibited the growth of gallbladder carcinoma GBC-SD cells and induction of apoptosis can be antagonized by PGE2 , indicating that Celecoxib inhibited the proliferation of GBC-SD cells and induction of withered The role of death by PGE2 pathway. Experiments show , Celecoxib can cause GBC-SD were G0/G1 cell cycle arrest. Tips and Celecoxib as a chemopreventive agent chemotherapy may be high COX -2 expression in gallbladder tumors. This gives us inspiration , to the use of highly selective COX -2 inhibitors in high-risk groups of primary gallbladder carcinoma ( gallbladder stones, gallbladder adenomatous polyps , cystic glandular hyperplasia of muscle , xanthogranulomatous cholecystitis and porcelain gallbladder Patients) in the prevention and control work , but also the use of COX -2 inhibitors effectively prevent postoperative recurrence and metastasis.
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