www.public4you.fora.pl

90nike5657fv

,[link widoczny dla zalogowanych]
Experimental cisplatin-induced acute renal failure animal models

Observation time is too short , the results failed to confirm that CP induced ARF is irreversible , but we can see the persistence of renal injury . Renal injury in the kidney of CP is its susceptibility to CP as the main organs of excretion . Cisplatin can combine many of the organelles and macromolecules , inhibit DNA, RNA synthesis,[link widoczny dla zalogowanych], inhibition of lysosomal , mitochondrial function ]. CP renal injury associated with renal plasma flow (RPF), glomerular filtration rate (GFR) and single glomerular filtration rate (SNGFR) in the fall. Research data show that ], rapid infusion of plasma to about 5 weight parts to improve the RPF, GFR, SNGFR can also be increased , suggesting that CP induced ARF , the first reduction in RPF occurred . RPF 's decline may be due to renal vasoconstriction . CP is the mechanism through which regulation of renal blood vessels , is still unclear ,[link widoczny dla zalogowanych], the kidney may be related to nitric oxide (NO) synthesis decreased about 0]. Our results show that tubular lumen have off debris, though failed to detect the small pipe pressure , but speculated that cell tube formation and the small tube plugging mechanisms involved in the CP chamber due to kidney damage. This study successfully established a CP -induced ARF model, but its exact mechanism is unknown. Vasoactive substances , cytokines ,[link widoczny dla zalogowanych], inflammatory neurotransmitters , apoptosis, cell adhesion molecules and other factors and the relationship between CP and the extent of induced ARF remains to be further experimental study .
More articles related to topics：

[link widoczny dla zalogowanych]

[link widoczny dla zalogowanych]

[link widoczny dla zalogowanych]