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Procyanidins on brain function in patients with Alzheimer's impact

Zou Rui, ZHU Liang, et al. LSPC on scopolamine induced memory impairment in mice that affect the mouth]. China Journal of Comparative Medicine,[link widoczny dla zalogowanych], 2006,9 (9): 572. Received date :2008-02-09; Revised :2008 -05-21 Editor: Li Zhi a lipoic acid treatment of elderly type 2 diabetic peripheral neuropathy concept Chaxia Wei, Zhang Ling,[link widoczny dla zalogowanych], Wen Shilin Abstract Objective: a-lipoic acid in elderly patients with type 2 diabetes mellitus peripheral neuropathy treatment effect. Methods: The elderly type 2 diabetic patients with peripheral neuropathy 8O,[link widoczny dla zalogowanych], were randomly divided into a treatment group and n amine drilling a lipoic acid treatment group, for 3 weeks, and clinical efficacy. Results: n a lipoic acid treatment group and mecobalamin group,[link widoczny dla zalogowanych], the total effective rate was significant difference (P 5m / s or return to normal; effect: awareness symptom relief,[link widoczny dla zalogowanych], improvement in Achilles tendon reflex, NCV increased <5m / s; invalid : no improvement or worsening symptoms, no improvement in the Achilles tendon reflex, NCV unchanged. Markedly effective and effective cases and the ratio of the total number of cases by: Henan People's Hospital of Endocrinology, Zhengzhou 450003, the total efficiency. 1.4 statistical software package using SPSS11.0, count data using test P <0.05 as significant difference. 2 efficacy results of two groups of patients the results shown in Table 1 Table 1 Comparison of efficacy of two groups of patients (cases) Note: The total effective rate was higher, P <0,05. 3 to discuss the pathogenesis of diabetic neuropathy is not clear, Brownlee_1 the unified mechanism theory that increased oxidative stress is a key cause of diabetes complications. Polyol and hexosamine pathways metabolic enhancement, advanced glycation end products, protein kinase C and NF-B activation, may be mediated by oxidative stress, reactive oxygen medium (R0s) increased, causing nerve damage. Oxidative stress can damage the nerve nutrition blood vessel endothelial function, the sciatic nerve induced diabetic rat model of endometrial arterioles diastolic dysfunction, hemodynamic changes, and then nerve ischemia, hypoxia, nitric oxide may be related to speed up the (N0) to eliminate live on; reactive oxygen species may also be a direct toxic effect media, damage neurons DNA, nerve proteins, neural lipids, impede axon and signal transduction; can also be caused by nerve growth factor such as nerve growth factor and ciliary neurotrophic factor reduction , thus weakening the ability to regenerate damaged nerve fibers. ~ Lipoic acid (AlphaLipoicAcid, LA) is a unique way of redox potent inhibitor of oxidative stress, as pyruvate dehydrogenase and a glutaric acid
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