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HPLC method for the determination of metronidazole in milk content of caesarean section

Operation under way to determine metronidazole concentration Northwest Pharmaceutical Journal December 2002 Volume 17 No. 6 of the RSD is 】 . 7. 2.5 recoveries test the milk before administration of precision drawing 1.0mL,[link widoczny dla zalogowanych], 6 copies , respectively, the scale set 5mL test tube,[link widoczny dla zalogowanych], were added to stock solution 0.2mL and 0.4mL, under preparation by standard curve method Operation ,[link widoczny dla zalogowanych], the results shown in Table 1. Table 1 The recoveries measured results obtained by adding the average recovery rate the amount of RSD / g / g (%)(%)() 4.03.92098.04.03.91297.84.03.84896.297 .11.38.07.96899.68.07.65695.7 :! :: 2.6 Precision lessons of determination and 5h 1h after intravenous infusion of milk each 1.0mL,[link widoczny dla zalogowanych], according to the standard curve method is under preparation , The results shown in Figure 1 and Table 2. Table 25 Cesarean section at the content of the milk in the number of metronidazole metronidazole content / (g · L) 1h5h1934a average 7.737.217.096.905.796.9402468100246 '810 Milk in the HPLC chromatogram of a metronidazole a blank Ib milk after a milk infusion ; 1 a metronidazole ; 2 - 3 SA established to discuss this sensitive and accurate method for clinical pharmacy research; Our results showed that the Cesarean section at the lower levels of metronidazole in milk . But if the large amount of baby milk intake will be leaving for metronidazole overdose infant adverse reactions. suggested the safety of antibiotic use after cesarean delivery Drugs.
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