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Sophora japonica L. and its extracts Pieces of bleeding in rats

,[link widoczny dla zalogowanych], P <0.05, a P <0.01; and the Secretary for Health and Sophora japonica l dose group, P <0.054.23 extracts effects on blood coagulation in rats in Table 5. 5 days after administration, (1) SJ carbon and rutin large and small doses, small doses of quercetin and tannin large and small doses can significantly reduce the prothrombin time (P <0.05 or P < 0.01), but the difference between groups was not significant; (2) 3 kinds of extracts could decrease the platelet aggregation rate (P <0.05 or P <0.01), but no difference among the groups significant; (3) prednisone acetate can significantly increase the fibrinogen concentration (P <0.05). While the other of the experimental samples of plasma fibrinogen had no significant effect. Table 53 extracts effects on blood coagulation in rats (± S) Note: compared with the control group, P <0.05, better than the raw materials, and traditional Chinese medicine to SJ as to rutin, quercetin and tannins that hemostatic effect of 3 major components have been studied and found that they are a procoagulant effect, which can rutin important component of the coagulation system increased the total number of platelets, platelet aggregation experiments in rutin, quercetin and tannin on rats showed no significant effect on fibrinogen, and lower platelet aggregation rate. Wen-Mei Chen, etc. The results also show that rutin inhibits platelet activating factor (PAF) induced platelet aggregation and platelet free calcium concentration increased ¨. This seems to be three kinds of extracts to promote coagulation of the blood, but is employed in the body under normal circumstances, there is coagulation of blood itself and anti-coagulation, fibrinolysis and anti-fibrinolytic system, two pairs of contradictions They maintain the unity of opposites. procoagulant drugs can speed up the process or prevent blood coagulation fibrinolysis, decreased vascular permeability, promoting blood vessel contraction and so on receipt of hemostasis. our results reflects the hemostatic mechanism of Sophora japonica L. not by means of a single link or play a role, but several aspects of the body to adjust through various channels, in a timely manner to achieve dynamic balance.