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Cisplatin -based treatment of advanced cancer pain of bone metastases Efficacy

Guangxi Medical University 1998SeptI15 (3) (12),[link widoczny dla zalogowanych], the effective rate was 88. 2.3 quality of life changes : Before treatment, patients with KPS of 55 points on average soil 2O,[link widoczny dla zalogowanych], and 75 after treatment of soil 15. After treatment,[link widoczny dla zalogowanych], patients showed significantly improved quality of life (P <0.05). 2.4 The change of the tumor : 2 down after chemotherapy were CR, 5 down by the PR, 9例NC, no progress reported. Effective (CR + PR) was 43 . 2.5 toxicity, side effects of this group was mainly leukopenia (1., I, l. 3,3,7 cases , respectively ), nausea and vomiting (I, I ., L. 3,10,3 cases , respectively ), BUN increased in 2 cases , 2 cases of auditory nerve toxicity , the symptomatic treatment , the symptoms were relieved. 3 Discussion of bone metastasis is a common complication of advanced cancer , these patients showed symptoms of bone pain is difficult to control the conduct of a serious impact on the patient's quality of life. Analgesics , particularly opioid , very good efficacy for controlling pain , but prone to addiction , is not yet very good promotion. Although palliative chemotherapy can not cure these patients with advanced cancer , but can still reduce symptoms , improve quality of life and prolong survival . Therefore, we use a broad spectrum anti-tumor , malignant tumor on a variety of Guangxi Medical University 1998Sept15 (3) tumors were effective DDP, to the impact of high-dose drug delivery , together with other anti-cancer drugs , the treatment of patients with advanced malignant bone l6 Transfer of patients, the results show that the program near the original tumor response rate was 43, while the improvement in pain and limited mobility efficiency is 94% and 88 , respectively , indicating that the DDP -based palliative chemotherapy can really control Pain symptoms, improve activity limitation and quality of life . Side effects of this group of mainly bone marrow suppression and gastrointestinal reactions, a low incidence of renal toxicity , the group 2 guillotine . High-dose DDP -based palliative chemotherapy, bone marrow suppression should be used with caution strong chemotherapy drugs, if needed , the dose should be reduced appropriately. In addition , we must pay attention to hydration, diuretic , and a pH of urine } to strengthen support for symptomatic treatment.
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