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Blu-ray of dexamethasone on retinal injury and mechanism of

NL) in the number of apoptotic cells and c-Fos protein expression in the changes of DXM in the fight against blue light-induced retinal injury and its mechanism. 1 Materials and methods 1.1 Animals and groups will be 8 ~ l0 week old female Lewis albino rats were 44 (purchased from Beijing Vital River Laboratory Animal Technology Co., Ltd.) were divided into 3 groups. DXM treatment group and one saline (Ns) group 20,[link widoczny dla zalogowanych], respectively, in abdominal Ophthalmology 26 January 2008 No. 1 way of death death, in the light of its peak after 8 ~ 16h. In this study, TUNEL technique showed that blue light can induce apoptosis in retinal photoreceptor cells, Blu-ray peak time after irradiation and other reports and wu have some differences, which may be used in the experiments because the two blue light intensity and exposure time in different. Proto-oncogene c-f0s is a immediate-early gene, c-Fos protein expression product is one of the nuclear transcription factor, and Jun proteins together constitute a nuclear transcription factor activator protein 1 (activatorprotein-l, AP-1), in neural the start of apoptosis has important regulatory role. Hafezi other study found that c_f0s knockout mice (c-f0sI.) Resistant to light-induced photoreceptor apoptosis, but the protective mechanisms and c-Fos protein in light-induced photoreceptor cell apoptosis is still not clear. Poon and so that light-induced photoreceptor apoptosis and retinal ONL of c-Fos protein expression in closely related. The results indicated that continuous exposure to blue light can induce retinal ONL of c-Fos protein expression and photoreceptor apoptosis, both in time and space distribution of Q are parallel, which indicated that the retina ONL in the c. Fos protein expression in blue light-induced photoreceptor cell apoptosis may play an important role. Injury from Blu-ray c-Fos protein expression in the retina part of point of view, Blu-ray exposure 0h, c-Fos protein mainly in the retinal INL and RGCL,[link widoczny dla zalogowanych], and then,[link widoczny dla zalogowanych], c-Fos protein mainly in the retinal ONL, blue in the inner retina after light exposure the INL and RGCL apoptosis does not appear that Blu-ray irradiation in the retina in the INL and GCL expression of c-Fos protein expression in the retinal ONL of c-Fos protein in different meaning, ONL in c-Fos protein expression and Blu-ray-induced apoptosis of photoreceptor cells is closely related to the retinal INL and GCL towel significance of c-Fos expression is not clear, pending further study. 3.2DXM Blu-ray on the retina and the mechanism of injury very early on that of glucocorticoids on the effective treatment of retinal light damage,[link widoczny dla zalogowanych], and that its mechanism may be inhibition of lipid peroxidation, reduce inflammation, decrease stability of membrane structure the free radical generation and toxicity. In recent years, studies have shown that DXM pretreatment inhibits c-fos proto-oncogene transcription. In view of c-Fos protein in blue light-induced photoreceptor cell apoptosis cascade play an important role, we investigate the protective effect of DXM after injury with the blue photoreceptor apoptosis and c-Fos protein expression the relationship between the DXM group showed that after irradiation in the retina ONL c-Fos protein expression was significantly reduced photoreceptor cell apoptosis was significantly reduced. Blu-ray injury in the retina that large doses of DXM pretreatment reduced ONL expression of c-Fos protein and inhibit photoreceptor apoptosis, decreased c-Fos protein expression may be critical in the protective effect of DEX. This intracellular signal transduction from the perspective of further clarified the mechanism of protective effect of DXM. Blu-ray damage to the retina DXM has a protective effect, which may be directly reduced by the expression of c-Fos protein to inhibit apoptosis of photoreceptor cells to achieve. Although now on Blu-ray induced photoreceptor apoptosis signaling pathways not yet entirely clear, but the signal control may be to save the photoreceptor cell apoptosis is an effective method for the treatment of retinal degenerative diseases has opened a new way.
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