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Weixiaotie mixture on Gastrointestinal Kinetics

Lei Q: falling from Table 4,[link widoczny dla zalogowanych], the blank rate of small intestine with model group,[link widoczny dla zalogowanych], the difference was statistically significant, suggesting that the control group animals, small intestine was higher than the model control group, indicating that successful model. Model control group animals and positive control group and dose group Weixiaotie mixture rate between animals,[link widoczny dla zalogowanych], small intestine,[link widoczny dla zalogowanych], highly statistically significant (P <0.01) or (P <0.05), model control group animals, small intestine prompted forward rate is lower than the above 2 groups, indicating that the dose of domperidone and the mixture of atropine Weixiaotie inhibition in animal models due to the small intestine, there to promote the role of the small intestine. 4 Discussion FD (functional dyspepsia) in the etiology and pathogenesis has not yet been clear. Some studies have shown: human gastrointestinal motility disorders caused by gastric motility disorders, FD edge that is the main pathological basis of L ¨. FD patients with postprandial gastric motility disorders caused by gastric emptying (the emptying of solid food in particular) was significantly delayed. And FD is often accompanied by gastric antrum, pylorus, duodenum coordinated motion abnormalities, clinical manifestations decreased antral contractility or complete lack of opening and closing abnormal pylorus, duodenum Delayed or irregular movement, and even reverse peristalsis , resulting in gastric antrum, pylorus, duodenum, reduce the number of coordinated motion. FD is also associated with small intestinal motility in some patients abnormal, showing small intestinal migrating motor complex (MMC) to reduce the incidence of, or even disappear, the small intestine to promote non-forward and reverse-phase activities of frequent jack C, so that delay intestinal transit time, and of symptoms consistent with FD L4l. Regulation of human gastrointestinal motility is a very complex process, it is subject to the inherent self-rhythmic movement smooth muscle, neural regulation and humoral regulation of multiple factors. FD patients with gastrointestinal motility disorders and reduced vagal tone, there is some correlation; FD patients motilin. . . Levels were also significantly lower, showing no fasting plasma motilin peak, or peak lower than normal after eating no obvious peak. Typical prokinetic drugs such as domperidone is a strong dopamine receptor antagonists, cisapride is selectively promote muscular plexus of intestinal acetylcholine release at postganglionic. In the present results, Weixiaotie mixture can promote the improvement of gastric emptying rate in normal mice, its role and domperidone is similar; Weixiaotie mixture on the role of the normal intestinal propulsive movement is equally clear. Resulting increase in FD patients that gastric emptying and intestinal propulsive motility in the stomach to play a mixture of clinical treatment of elimination basis. Study confirmed that the main Weixiaotie mixture drug citrus aurantium, Magnolia can increase acetylcholinesterase and plasma motilin levels, thereby raising the tension and gastric emptying in rats 【, 6l. Contained in the nuts can be excited M arecoline increased gastrointestinal smooth muscle receptors to increase gastrointestinal motility. Citrus has a role to promote gastrointestinal motility, this effect may be achieved by excitatory receptor M L. The data also show that Weixiaotie mixture partially reversed the small intestine caused by inhibition of atropine, suggesting that some of Weixiaotie mixture pharmacological effects, may be excited by increasing M receptors to achieve. But the mixture of different doses of Weixiaotie dose-effect relationship between the two groups is not obvious, such as Weixiaotie mixture of low, medium dose group can promote gastric emptying, high-dose group and the difference between the control of gastric emptying, there was no statistically significant significance. Other data also showed that low concentrations of certain traditional Chinese medicine could increase gastrointestinal smooth muscle, high concentrations were inhibitory Shique 【8J, therefore, in the clinic, treatment of FD Weixiaotie mixture should fully consider the impact on the efficacy of drug concentrations. '
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